業績集

英文

・2020年
(27) Yanagida K., Valentine WJ. Druggable Lysophospholipid Signaling Pathways. Adv. Exp. Med. Biol., 1274, 137-176 (2020)

(26) Hishikawa D., Yanagida K., Nagata K., Kanatani A., Iizuka Y., Hamano F., Yasuda M., Okamura T., Shindou H., Shimizu T. Hepatic levels of DHA-containing phospholipids instruct SREBP1-mediated synthesis and systemic delivery of polyunsaturated fatty acids. iScience, 101495 (2020)

(25) Geng Z., Yanagida K., Akwii RG. Choi D., Chen L., Ho YC., Cha B., Mahamud MR., de Ruiz KB., Ichise H., Chen H., Wythe J., Mikelis CM., Hla T., Srinivasan RS. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling. JCI Insight. 5, 137652(2020)

(24) Yanagida K., Engelbrecht E., Niaudet C., Jung B., Gaengel K., Holton K., Swendeman SL., Liu CH., Levesque MV., Kuo A., Fu Z., Smith LEH., Betsholtz C., Hla T. Sphingosine 1-phosphate receptor signaling establishes AP-1 gradients to allow for retinal endothelial cell specialization. Dev. Cell. 52, 779-793 (2020)

・2019年
(23) Hisano Y., Kono M., Cartier A., Engelbrecht E., Kano K., Kawakami K., Xiong Y., Piao W., Galvani S., Yanagida K., Kuo A., Ono Y., Ishida S., Aoki J., Proia R.L., Bromberg J.S., Inoue A., Hla T. Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes. J. Exp. Med. 216, 1582-1598 (2019)

・2018年
(22) Yanagida K., Igarashi H., Yasuda D., Kobayashi D., Ohto-Nakanishi T., Akahoshi N., Sekiba A., Toyoda T., Ishijima T., Nakai Y., Shojima N., Kubota N., Abe K., Kadowaki T., Ishii S., Shimizu T. The Ga12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity. JCI Insight. 3, pii 97293 (2018)

(21) Nakanishi Y., Tan M., Ichiki T., Inoue A., Yoshihara JI., Maekawa N., Takenoshita I., Yanagida K., Yamahira S., Yamaguchi S., Aoki J., Nagamune T., Yokomizo T., Shimizu T., Nakamura M. Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4. Sci. Signal. 11, pii eaao5390 (2018)

(20) Masago K., Kihara Y., Yanagida K., Hamano F., Nakagawa S., Niwa M., Shimizu T. Lysophosphatidic acid receptor, LPA6, regulates endothelial blood-brain barrier function: Implication for hepatic encephalopathy. Bichem. Biophys. Res. Commun. 501, 1048-1054 (2018)

(19) Tsukahara R., Yamamoto S., Yoshikawa K., Gotoh M., Tsukahara T., Neyama H., Ishii S., Akahoshi N., Yanagida K., Sumida H., Araki M., Araki K., Yamamura KI., Murakami-Murofushi K., Ueda H. LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model. J. Pharmacol. Sci. 136, 93-96 (2018)

・2017年
(18) Yanagida K., Hla T. A dark side to omega-3 fatty acids. Nature 552, 180-181 (2017)

(17) Kono M., Conlon EG., Lux SY., Yanagida K., Hla T., Proia RL. Bioluminescence imaging of G protein-coupled receptor activation in living mice. Nat. Commun. 8, 1163 (2017)

(16) Swendeman SL., Xiong Y., Cantalupo A., Yuan H., Burg N., Hisano Y., Cartier A., Liu CH., Engelbrecht E., Blaho V., Zhang Y., Yanagida K., Galvani S., Obinata H., Salmon JE., Sanchez T., Di Lorenzo A., Hla T. An engineered S1P chaperone attenuates hypertension and ischemic injury. Sci. Signal. 10, pii eaal2722 (2017)

(15) Yanagida K., Liu CH., Faraco G., Galvani S., Smith HK., Burg N., Anrather J., Sanchez T., Iadecola C., Hla T. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proc. Natl. Acad. Sci. USA. 114, 4531-4536 (2017)

(14) Yanagida K., Hla T. Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. Ann. Rev. Physiol. 79, 67-91 (2017)

・2014年
(13) Sumida H., Yanagida, K., Kita Y., Abe J., Matsushima K., Nakamura M., Ishii S., Sato S., Shimizu T. Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis. J. Immunol. 192, 4361-4369 (2014)

(12) Hikiji H., Endo D., Horie K., Harayama T., Akahoshi N., Igarashi H., Kihara Y., Yanagida, K., Takeda J., Koji T., Shimizu T., and Ishii S. TDAG8 activation inhibits osteoclastic bone resorption. FASEB J. 28, 871-879 (2014)

・2013年
(11) Sumida H., Nakamura K., Yanagida, K., Ohkawa R., Asano Y., Kadono T., Tamaki K., Igarashi K., Aoki J., Sato S., Ishii S., Shimizu T., and Yatomi Y. Decrease in circulating autotaxin by oral administration of prednisolone. Clin. Chim. Acta. 415, 74-80 (2013)

・2012年
(10) Yanagida, K., Kurikawa Y., Shimizu T., and Ishii S. Current progress in non-Edg family LPA receptor research. Biochim. Biophys. Acta. 1831, 33-41 (2012)

(9) Eto M., Shindou H., Koeberle A., Harayama H., Yanagida, K., and Shimizu T. Lysophosphatidylcholine Acyltransferase 3 Is the Key Enzyme for Incorporating Arachidonic Acid into Glycerophospholipids during Adipocyte Differentiation. Int. J. Mol. Sci. 13, 16267-16280 (2012)

(8) Komachi M., Sato K., Tobo M., Mogi C., Yamada T., Ohta H., Tomura H., Kimura T., Im DS., Yanagida, K., Ishii S., Takeyoshi I., and Okajima F. Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo. Cancer Sci. 103, 1099-1104 (2012)

・2011年
(7) Yanagida, K. and Ishii S. Non-Edg family LPA receptors: the cutting edge of LPA research. J. Biochem. 150, 223-232 (2011)

・2010年
(6) Ihara Y., Kihara Y., Hamano F., Yanagida, K., Morishita Y., Kunita A., Yamori T., Fukayama M., Aburatani H., Shimizu T., and Ishii S. The G protein-coupled receptor T-cell deathassociated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor. Proc. Natl. Acad. Sci. USA.107, 17309-17314 (2010)

(5) Sumida H., Noguchi K., Kihara Y., Abe M., Yanagida, K., Hamano F., Sato S., Tamaki K., Morishita Y., Kano MR., Iwata C., Miyazono K., Sakimura K., Shimizu T., and Ishii S. LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis. Blood 116, 5060-5070 (2010)

・2009年
(4) Ishii, S., Noguchi, K., and Yanagida, K. Non-Edg family lysophosphatidic acid (LPA) receptors. Prostaglandins Other Lipid Mediat. 89, 57-65 (2009)

(3) Yanagida, K., Masago, K., Nakanishi, H., Kihara, Y., Hamano, F., Tajima, Y., Taguchi, R., Shimizu T., and Ishii, S. Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. J. Biol. Chem. 284, 17731-17741 (2009)

・2008年
(2) Kihara, Y., Yanagida, K., Masago, K., Kita, Y., Hishikawa, D., Shindou, H., Ishii, S., and Shimizu, T. Platelet-Activating Factor Production in the Spinal Cord of Experimental Allergic Encephalomyelitis Mice via the Group IVA Cytosolic PLA2-LysoPAFAT Axis. J. Immunol. 181 5008-5014 (2008)

・2007年
(1) Yanagida, K., Ishii, S., Hamano, F., Noguchi, K., and Shimizu, T. LPA4/p2y9/GPR23 mediates Rho-dependent morphological changes in a rat neuronal cell line. J. Biol. Chem. 282, 5814-5824 (2007)

和文総説等

・2020年
(2) 石井聡, 柳田圭介 Non-EDG型LPA受容体 : 生化学,立体構造,生理機能. 生化学 90, 596-608 (2018)

・2010年
(1) 柳田圭介, 石井聡リゾホスファチジン酸受容体研究Update. 医学のあゆみ 233, 807-811 (2010)

研究費獲得状況

科研費等 (代表)

2020-2023年度　革新的先端研究開発支援事業　(AMED-PRIME)

2020-2022年度　科学技術研究費　基盤研究(C)

2010-2011年度　科学技術研究費補助金研究活動スタート支援

財団・学会等

2019年度　アステラス病態代謝研究会研究助成

2020年度　細胞科学財団研究助成

2020年度　三菱財団自然科学研究助成若手研究助成

2020年度　日本応用酵素協会　酵素研究助成

2020年度　武田科学振興財団　医学研究助成

2020年度　日本応用酵素協会　Vascular Biology Innovationに関する研究助成　(VBIC)

2020年度　上原記念生命科学財団　研究奨励金